PP87 Evaluation of the Antidepressant Activity of a Dichloromethane Fraction from Hypericum mexicanum L.: New Doses and Chemical Characterization
DOI:
https://doi.org/10.3407/rpn.v6i1pp87Keywords:
Hypericum mexicanum, depression, chemical composition, forced swimming test, tail suspension test, FlavonoidsAbstract
Depression is one of the most common mental disorders and represents a public health challenge due to its impact on the quality of life of affected individuals and the financial burden on healthcare systems [1]. Despite advances in its treatment, there is still a need to find more effective therapies with fewer side effects [2].
References
[1] WORLD HEALTH ORGANIZATION. (2017). *Depression and other common mental disorders: Global health estimates*. Geneva: WHO. [URL]
[2] GONDA, X., DOME, P., NEILL, J. C., & TARAZI, F. I. (2023). Novel antidepressant drugs: Beyond monoamine targets. *CNS Spectrums*, 28(1): 6–15. [DOI]
[3] BUTTERWECK, V., JÜRGENLIEMK, G., NAHRSTEDT, A., & WINTERHOFF, H. (2000). Flavonoids from *Hypericum perforatum* show antidepressant activity in the forced swimming test. *Planta Medica*, 66(1): 3–6. [DOI]
[4] CROCKETT, S. L., & ROBSON, N. K. (2011). Taxonomy and chemotaxonomy of the genus *Hypericum*. *Medicinal and Aromatic Plant Science and Biotechnology*, 5(Special Issue 1): 1–13. [URL]
[5] DUARTE ABADÍA, B., & OSEJO VARONA, A. (2016). *Plantas del páramo y sus usos para el buen vivir*. Biblioteca Digital de Bogotá. [URL]
Consultado el 06-12-2024.
[6] GARCÍA, A., GUTIÉRREZ OSORIO, M., & PINEDA FORERO, M. (2014). *Las maticas de mi región*. Bogotá, Colombia: Jardín Botánico de Bogotá José Celestino Mutis. [URL] *(URL general, el libro no tiene enlace directo público)*
[7] TOCCI, N., WEIL, T., PERENZONI, D., MORETTO, M., NÜRK, N., MADRIÑÁN, S., FERRAZZA, R., GUELLA, G., & MATTIVI, F. (2020). Potent antifungal properties of dimeric acylphloroglucinols from *Hypericum mexicanum* and mechanism of action of a highly active 3'-prenyl uliginosin B. *Metabolites*, 10(11): 459. [DOI]
Downloads
Published
Issue
Section
Categories
License
Copyright (c) 2026 Andrés F. SOLÓRZANO-MORALES; Luz A. CHICUASUQUE-RODRIGUEZ, Mario Francisco GUERRERO-PABÓN, Juan Camilo MARÍN-LOAIZA
This work is licensed under a Creative Commons Attribution 4.0 International License.
License Terms
The Creative Commons Attribution License (CC BY 4.0) allows users to copy, distribute and transmit an article and adapt the article and make commercial use of the article. The CC BY license permits commercial and non-commercial re-use of an open access article, as long as the author is properly attributed.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
- You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation.
- No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity.
