The "REVISTA PRODUCTOS NATURALES" (ISSN 1916-2413) is an open access electronic publishing, of specialized scientific spreading of free access, that invites and publishes articles of fundamental and applied research with substantial contributions in science, technology, and industry of natural products from plant, animal or microbial origin, as much terrestrial as marine organisms. "The Revista Productos Naturales” is completely free for both authors and readers. There are no publication or access costs, ensuring that knowledge and research are available to everyone without economic barriers. For preservation and archiving, the "Revista Productos Naturales" is available online, ensuring that the content is accessible and preserved digitally, including CLOCKSS, LOCKSS, Internet Archive, and PKP PN. This digital medium helps in maintaining the longevity and accessibility of published research.
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PO42 Mini-Review On Kalanchoe spp.: Phytochemical Composition, Biological Properties, and Research Perspectives in Colombia
The species Kalanchoe pinnata has been widely studied for its phytochemical and bioactive properties, including antioxidant, anti-inflammatory, and potential anticancer activity [1]. Through this mini-review, 33 articles published in scientific journals such as Revista Brasileira de Farmacognosia, BMC, SciELO, Rev. Colomb. Cienc. Quím., South Florida Journal of Development, and Natural Product Communications between 2015 and 2024 were analyzed, aiming to consolidate knowledge about this plant and its application in health.
I Colombian Congress of Natural Products (2025)
Copyright (c) 2025 Nina María SANCHEZ RAMIREZ, Jhon Fredy Castañeda Gómez, Yurani Aleyda Cuetumbo Aposta, María Alejandra Pulido Zabaleta, Natalia Santofimio Gaviria https://creativecommons.org/licenses/by/4.0
PO9 Road to Strengthening Research in Natural Products. View from the Technological University of Uruguay
In Uruguay, where Montevideo concentrates much of the educational and scientific infrastructure, the expansion of areas such as natural products in institutions in the interior has been key to regional development. This is reflected in impactful projects, such as clinics, theses, and workshops, that explore various aspects of these products. These projects have allowed students and professionals to become involved in the research and development of new products, fostering knowledge exchange between different regions.
Copyright (c) 2025 María Rossina Figliolo Mederos, Jhonatan Cardozo, Annabela Estévez Onetto https://creativecommons.org/licenses/by/4.0
CP2 Small Organic Molecules from Natural Sources: The End of an Era?
The multinational pharmaceutical industry (Big Pharma) has transitioned towards the development of macromolecules through heterologous production platforms, aiming to protect substantial financial investments associated with developing new therapies.
Copyright (c) 2025 Guillermo León Montoya Peláez https://creativecommons.org/licenses/by/4.0
El Premio Juan Martínez Valderrama ha sido instaurado en el marco del I Congreso Colombiano de Productos Naturales (2025) con el firme propósito de reconocer la excelencia académica y científica de los participantes a mejores posters y presentaciones orales en las categorías: Senior, Posgrado y Pregrado. Este galardón honra la memoria del distinguido investigador Juan Martínez Valderrama (Febrero 24 de 1944 – Enero 4 de 2024), cuyo legado en el campo de los productos naturales ha sido fundamental para el avance de la ciencia en Colombia y en el mundo.
Copyright (c) 2025 José Hipólito Isaza Martínez https://creativecommons.org/licenses/by/4.0
ED Editorial del I Congreso Colombiano de Productos Naturales
En el año 2025, con gran orgullo y satisfacción, nos complace anunciar la realización del "I Congreso Colombiano de Productos Naturales". Esta nueva denominación representa un paso adelante en la evolución del congreso, abriendo sus puertas a una gama más amplia de temas y enfoques relacionados con los productos naturales. El congreso sigue siendo un espacio para el intercambio de ideas innovadoras, la presentación de investigaciones de vanguardia y la creación de redes de colaboración entre académicos, empresarios, profesionales y estudiantes.
PI-3 Committees of the 1st Colombian Congress of Natural Products (2025)
The document outlines the committees for the I Colombian Congress on Natural Products scheduled for 2025, detailing the members of the Organizing Committee, Scientific Committee, and Editorial Committee, including their affiliations and roles.
PI-2 Agradecimientos a nuestros patrocinadores
El Comité Organizador del “I Congreso Colombiano de Productos Naturales (2025)” desea expresar su más sincero agradecimiento a las empresas que han hecho posible la realización de este evento. Su apoyo ha sido fundamental para llevar a cabo este congreso y promover el desarrollo y conocimiento de los productos naturales en Colombia.
PI-1 Nota histórica del cambio de nombre del Congreso Colombiano de Fitoquímica al Congreso Colombiano de Productos Naturales
Con el fin de honrar esta diversidad de fuentes de productos naturales, los participantes del XIV Congreso Colombiano de Fitoquímica decidieron por consenso cambiar el nombre del evento a "Congreso Colombiano de Productos Naturales". Este cambio refleja la ampliación del enfoque del congreso, abarcando no solo la fitoquímica, sino también otros productos naturales y las nuevas tendencias como las ciencias ómicas y la educación.
PP89 Antioxidant activity of Ganoderma lucidum evaluated by electrochemical assays
This study investigated the antioxidant activity and electrochemical behavior of the fungus G. lucidum using electrochemical techniques. Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were performed in a three-electrode system, utilizing glassy carbon as the working electrode, Ag/AgCl as the reference electrode, and a platinum rod as the auxiliary electrode, in a 0.02 M acetate buffer solution (pH 5.0). G. lucidum exhibited antioxidant activity, suggesting an electroactive chemical composition. Furthermore, the Epa for G. lucidum was more anodic with respect to the standards ascorbic acid and gallic acid
Copyright (c) 2025 Jaime Fernando Martínez Suárez, Lisette Dyanna Ruiz Bravo, Olga Lucía Benavides Calvache https://creativecommons.org/licenses/by/4.0
PP62 Study of the Bioactive Compounds of Apis mellifera honey obtained from Eugenia stipitata (Arazá).
In the present study, five types of honey were evaluated: two containing Arazá floral nectar (Arazá honey) (M001, M002) collected in the department of Caquetá, and three others from southern Colombia. The characteristics of these honeys were evaluated by examining their physicochemical properties, color, and their constituent compounds, which were confirmed by GC-MS analysis. Fifteen phenolic compounds were detected in honey sample M002, the most abundant phenolic compounds tentatively detected were 3,4-dihydroxybenzoic acid, salicylic acid, caffeic acid, chlorogenic acid, pcumaric acid, ferulic acid, gallic acid, syringic acid, isorhamnetin, kaempferol, luteolin, naringenin, pinobanksin, quercetin and rutin
Copyright (c) 2025 Liceth Natalia Cuellar Alvarez, Yina Herrera, Mayrin O. Valencia, Jhon Ironzi Maldonado, Alejandro García Rios https://creativecommons.org/licenses/by/4.0
PP56 Chemical properties of Apis mellifera honey (Hymenoptera: Apidae) produced in the Colombian Amazon.
This study aimed to evaluate the physicochemical parameters, chemical composition, and antioxidant and antimicrobial activities of honeys collected from five localities in Caquetá. Physicochemical parameters were considered. Additionally, antioxidant properties were evaluated using the DPPH (9.0% - 18.0% inhibition), FRAP (130.0 - 450.0 μmol Fe²⁺/kg of honey), and ORAC (1300 - 4000 μmol TE/g of honey) methods. Antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans was also analyzed, yielding promising results that support the therapeutic potential of honey produced in the Colombian Amazon.
Copyright (c) 2025 Liceth Natalia Cuellar Alvarez, Mayrin O. Valencia, Jhon Ironzi Maldonado, Yina HERRERA, Alejandro Garcia Rios https://creativecommons.org/licenses/by/4.0
PP28 Obtaining functional cookies from copoazú (Theobroma grandiflorum) pulp
The objective of this study was to develop functional cookies from cupuassu ( Theobroma grandiflorum) pulp, and their physicochemical and sensory properties were evaluated. Sensory analysis was performed with a trained panel of 10 individuals (5 men and 5 women). The treatment that showed the best attributes was that with proportions of (5:20:75) (Sweetener: Ingredients: Pulp). The cookies exhibited a considerable amount of vitamins, such as Vitamin C (6.15 mg/100 g DW). Furthermore, a significantly higher phenolic content was observed in the cookies with the addition of cupuassu pulp (235 mg GAE/100 g).
Functional foods, Copoazú, Amazonian fruit, Antioxidants, Vitamin C.
Copyright (c) 2025 Liceth Natalia Cuellar Alvarez, Wilson RODRIGUEZ, Gloria M. PALADINES https://creativecommons.org/licenses/by/4.0
PP35 Antihypertensive potential of extracts pulp Theobroma grandiflorum amazonian fruit
The objective of this study was to characterize, using liquid chromatography coupled with mass spectrometry analysis, together with the evaluation of the in vitro antihypertensive activity of the pulp of Copoazú fruits. The chromatographic profile of the extract obtained with ethyl acetate indicated the presence of polyphenols such as gallic acid, and other metabolites with biological potential. Likewise, the in vitro antihypertensive activity evaluated through the ACE-I enzyme inhibition assay showed that the extract enriched in ethyl acetate obtained a percentage of inhibition compared to another Amazonian fruit
Theobroma grandiflorum; antihypertensive activity; polyphenols; Amazonian fruit.
PP94 Electrochemical determination of the antioxidant activity of Laetiporus sulphureus
The electrochemical behavior and antioxidant activity of L. sulphureus was performed by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). For CV and DPV, a three-electrode system was used: glassy carbon working electrode, Ag/AgCl reference electrode, and platinum auxiliary electrode, using a 0.02 M acetate buffer (pH 5.0). The electrochemical behavior of L. sulphureus showed an irreversible charge transfer process centered at an anodic peak potential (Epa) of 0.52 V. Ascorbic acid presented an Epa of 0.29 V, while gallic acid exhibited two anodic peaks, at 0.41 V and 0.69 V.
Antioxidant activity, electrochemical techniques.
Copyright (c) 2025 Lisette Dyanna Ruiz Bravo, Jaime Fernando Martínez Suárez, Olga Lucía Benavides Calvache https://creativecommons.org/licenses/by/4.0
PP68 EVALUACIÓN DE LA ACTIVIDAD ANTIOXIDANTE Y ANÁLISIS DE METABOLITOS EN OCHO ESPECIES DE MACROMICETOS AMAZÓNICOS DE LOS ÓRDENES POLYPORALES Y AGARICALES MEDIANTE GC-MS Y LC-MS.
Macromycetes are fungi with visible fruiting bodies that are a valuable source of nutrients and bioactive compounds [1]. Its chemical composition includes fatty acids, vitamins, phenolic compounds, and terpenoids, which possess antioxidant, anti-inflammatory, and antimicrobial properties. These characteristics make them relevant for the prevention of chronic diseases and their possible applications in the pharmaceutical and food industries
Copyright (c) 2026 Julieth Cano, Laura Orozco, Chiara Carazzone, Gerson Dirceu, Paula Galeano https://creativecommons.org/licenses/by/4.0
PO57 Untargeted Metabolomic Analysis by LC-MS for the differentiation of arazá (Eugenia stipitata) subspecies.
Eugenia stipitata is a perennial tree belonging to the Myrtaceae family that is native to the Amazon rainforest. It was characterized by McVaugh in 1956 based on samples collected in Peru, Brazil, Bolivia, and Colombia.
Copyright (c) 2025 Paula Liliana Galeano García, Elena Ibañez, Alejandro Cifuentes, Alberto Valdes, Jose Mendiola https://creativecommons.org/licenses/by/4.0
PP7 Evaluation of the effect of solvent on the content of phenolic compounds and antioxidant activity in fresh and dried peel of honey gold pineapple and India Caqueteña.
Pineapple (Ananas comosus) processing generates significant agro-industrial waste, mainly peels, accounting for up to 50% of the fruit [1]. These residues may contain more bioactive compounds than the edible portion [3,4]. This study evaluated the effect of solvent (70% methanol and acetone) and peel condition (fresh and dried) in two pineapple varieties [2,5]. Ultrasound-assisted extraction was applied. Dried peels extracted with acetone showed the highest phenolic content and antioxidant activity in the INDIA variety. IR-ATR analysis confirmed functional groups associated with phenolic structures, highlighting the potential for sustainable valorization of these by-products.
Bioactive compounds, phenolic compounds, antioxidant activity, agro-industrial waste.
Copyright (c) 2025 Nathalia A. Venegas, Paula Galeano, Gloria Magally Paladines Beltrán https://creativecommons.org/licenses/by/4.0
PP95 Extraction and characterization of bioactive compounds in fruit residues from the Colombian Amazon
The agricultural sector generates underutilized plant residues that may pollute the environment [1,2]. This study evaluated peels, husks, and seeds of Myrciaria dubia, Bactris gasipaes, Eugenia stipitata, and Arbutus unedo as sources of bioactive compounds [3]. Ultrasound-assisted extraction was applied to fresh and dried samples using 70% methanol and acetone. Dried peels and husks extracted with acetone showed the highest phenolic content and antioxidant activity. IR-ATR analysis confirmed functional groups associated with phenolics. Results highlight the potential of these by-products for sustainable applications in food and cosmetic industries.
Copyright (c) 2026 Gloria M. Paladines, Nathalia A. Venegas, Paula Galeano https://creativecommons.org/licenses/by/4.0
PP14 Exploitation of copoazú (Theobroma grandiflorum) seed husk: Evaluation of bioactive compounds and antioxidant activity
Cupuaçu (Theobroma grandiflorum) is a valuable Amazonian fruit, whose seeds generate by-products such as the husk, which are often underutilized [1,2]. Given its nutritional potential and similarity to cocoa husk [3], this study evaluated the extraction of bioactive compounds from cupuaçu seed husk using ultrasound-assisted extraction (UAE) and conventional extraction (CE). UAE with 70% ethanol for 75–120 minutes improved the recovery of nutritional compounds, phenolics, flavonoids, and antioxidant activity compared to CE, which required 96 hours [4]. These findings highlight the efficiency of UAE for valorizing agro-industrial residues.
Bioactive compounds, Bioactive compounds, Nutritional compounds, Extraction, ultrasound
Copyright (c) 2025 Gloria M. Paladines, Nathalia A. Venegas, Valentina Vargas https://creativecommons.org/licenses/by/4.0
PP21 Effect of the Spray Drying Process on the Encapsulation of Amazonian Fruit Pulp Enriched with cupuacu (Theobroma grandiflorum) Seed Extract
Cupuassu and açaí are fruits known for their richness in bioactive compounds, although their utilization is limited due to their high perishability and the traditional use of their seeds [1–3]. This study evaluated the optimization of spray drying to encapsulate cupuassu and açaí pulps, incorporating cupuassu seed extract. A central composite design was applied to analyze the effect of three variables on bioactive and physical properties. The optimal conditions (165 °C, 9.6% maltodextrin, 11.3% extract) resulted in high compound retention, good yield, and low moisture content, enhancing the stability of the final product [4,5].
Bioactive compounds, spray drying, central composite design (CCD), response surface methodology (RSM).
Copyright (c) 2025 Valentina Vargas, Nathalia A. Venegas, Liceth N. Cuellar, Andrea Hermosa, Wilson Rodríguez, Gloria M. Paladines https://creativecommons.org/licenses/by/4.0
PO52 Preliminary Phytochemical Evaluation and Antimicrobial Activity Analysis of Extracts Derived from Residual Biomass of Coffee Cherry and Coffee Parchment Against Microorganisms Associated with the Oral Microbiota
Coffee is among the most widely consumed beverages globally, resulting in the generation of substantial volumes of plant-based waste. During the harvesting and processing stages of coffee beans, significant amounts of by-products are produced, notably coffee cherry and coffee parchment. If not properly managed, these residues can become a major source of environmental pollution.
Copyright (c) 2025 Luis Gonzalo Sequeda Castañeda, María Camila Briceño-Chagüí , Yani Leandro Lozada-Poveda , Mayra Alexandra Téllez-Corral, Jean Carlos Villamil-Poveda, Sandra Janeth Gutiérrez-Prieto https://creativecommons.org/licenses/by/4.0
PO60 Extraction of antioxidants from chontaduro (Bactris gasipaes) peel using supercritical carbon dioxide
The "chontaduro" fruit (Bactris gasipaes) is a plant-based product of Amazonian origin that is marketed in several regions of Colombia and is even exported. However, its peel is an agro-industrial byproduct rich in carotenoids—compounds with significant antioxidant activity that are highly valued in the food, nutraceutical, and pharmaceutical industries.
Copyright (c) 2025 Carlos Esteban Zapata, Juan David Rivera, Isabel Mejía, Gustavo E. Bolaños https://creativecommons.org/licenses/by/4.0
PO59 Photoprotective activity of extracts from native Amazonian plants: an exploratory study
Extended exposure to solar radiation in humans is currently a public health concern due to the carcinogenic effects of ultraviolet (UV) radiation [1]. One of the most effective strategies to mitigate its effects is the use of photoprotective agents. However, the active ingredients in sunscreens, both chemical and physical UV filters, have raised increasing concern due to their toxicity in humans [2], their impact on marine ecosystems, and their low biodegradability.
Juliana Erika Cristina Cardona Jaramillo
Copyright (c) 2025 Marcela Piedad Carrillo Bautista, Juliana Erika Cristina Cardona Jaramillo, Gustavo E. Bolaños https://creativecommons.org/licenses/by/4.0
CP8 Biocommunicators for parasitic weed control: honeypot strategy
Parasitic weeds pose a significant threat to agricultural productivity, necessitating the development of sustainable control methods. Traditional herbicides have led to the emergence of resistant weed varieties, underscoring the urgent need for environmentally friendly and effective alternatives.
Copyright (c) 2025 Francisco Antonio Macías Domínguez, Jesús G. Zorrilla, Carlos Rial; Antonio Cala Peralta; Francisco J. Rodríguez-Mejías, Rosa María Varela Montoya, José María González Molinillo https://creativecommons.org/licenses/by/4.0
PP41 Antifungal Activity of Ethanolic Extract of Ripe Seeds from Azadirachta indica against Pestalotia sp in Coffee Leaf – Experimental Farm Pueblo Bello, Cesar
Coffee in Colombia is one of the agricultural products with the greatest social, industrial, and economic importance, reaching almost 70 countries and making it one of the most recognized and widely distributed Colombian products worldwide. This crop is affected by various fungal diseases that can impact productivity and cause economic losses [1].
Copyright (c) 2025 Lenka Victoria Tamayo Lopez, Diego Camilo Durán, Aslenis Melo Ríos, Pedro J. Fragoso-Castilla, Anahy Desireth Rodriguez Ovalle https://creativecommons.org/licenses/by/4.0
PP55 Influence of microencapsulation on the stability and evaluation of the antimicrobial activity of essential oils from the Lamiaceae family
Skin infections, such as acne, are a common reason for dermatological consultations and are associated with pathogens like Staphylococcus aureus and Propionibacterium acnes. Although antimicrobials are used, bacterial resistance has spurred the search for alternatives, such as essential oils (EO), whose bioactive compounds possess antiseptic properties. However, their volatility limits their application, which is why microencapsulation emerges as a strategy to improve their stability. This study prioritized four plant species rich in monoterpenes and evaluated three microencapsulation methods. Both free and encapsulated EO demonstrated antibacterial activity, highlighting their potential in dermatological formulations.
Copyright (c) 2025 William Ramiro PATIÑO BAYONA, Sintia Juliet Garzon Restrepo https://creativecommons.org/licenses/by/4.0
PO22 Larvicidal effect of hexane and ethyl acetate extracts of Austroeupatorium inulifolium on fourth-instar larvae of Aedes aegypti
The larvicidal, cytotoxic, and allelochemical effects of Austroeupatorium inulifolium extracts obtained with hexane and ethyl acetate were evaluated. Bioassays were conducted against fourth-instar larvae of Aedes aegypti, showing high efficacy of the ethyl acetate extract (lowest LD₅₀). Cytotoxicity in VERO cells was found to be non-toxic, and no significant allelochemical effects were observed in Lactuca sativa. GC-MS analysis identified compounds such as β-caryophyllene, phytol, and hexadecanoic acid. The results support the potential of this species as a source of bioactive compounds for biological vector control and integrated ecological management.
Copyright (c) 2025 M.Q. Jorge I. Sierra Acevedo, Dra. Eunice R, Vasquez, Dr. Jaime A. Marin Colorado https://creativecommons.org/licenses/by/4.0
PO33 The Reality of Cannabinoids as a Therapeutic Alternative
Pain and its associated repercussions in multiple pathologies continue to be one of the most prevalent health problems worldwide, significantly affecting the quality of life of millions of people. In the search for effective therapeutic alternatives with fewer side effects than conventional analgesics, cannabinoids have been explored as a therapeutic option for many years in various medical specialties, including Rheumatology, Oncology, Neurology, Physical Medicine, and Internal Medicine.
Copyright (c) 2025 Carlos Rafael FAJARDO PINILLA https://creativecommons.org/licenses/by/4.0
PP76 Chemical and Antimicrobial Potential of Endophytic Fungi from Tibouchina urivellana
Endophytic fungi are symbiotic microorganisms that reside the internal tissues of plantas, and have coevolved with their hosts, developing remarkable biosynthetic capabilities to produce complex secondary metabolites with remarkable antimicrobial, antiviral, and anticancer potential
Copyright (c) 2025 Jeisson Javier Martínez Vargas, Daniel Felipe QUIROGA, Gabriel Esteban LEGUIZAMÓN, Erika Andrea Plazas Gonzalez https://creativecommons.org/licenses/by/4.0
PP33 SCIENTOMETRIC STUDY OF THE SCIENTIFIC PRODUCTION PUBLISHED DURING THE YEARS 2010 TO 2020 FOR PLANT SPECIES OF THE ERICACEAE FAMILY
The Ericaceae family has many genera and species, some of which have been the subject of chemical and biological studies to identify and isolate secondary metabolites that may be biologically important. Research on species in this family has identified the presence of important secondary metabolites, including flavonoids and terpenes, which have been used as chemotaxonomic markers
Ericaceae, especies vegetales, metabolitos secundarios, cienciometría, actividad biológica
Copyright (c) 2025 Luz Andrea Jiménez Molina, William Fernando Castrillón Cardona, Javier Andrés Matulevich Pelaéz, Wendy Tatiana Rosas Bravo, Diego Alejandro Silva Carrero https://creativecommons.org/licenses/by/4.0