PO58 Drug interaction between curcuma and the antidepressant fluoxetine on behavioral despair and biochemical markers of kidney and liver function in Wistar rats
DOI:
https://doi.org/10.3407/2bsxyh35Keywords:
fluoxetine, curcuma, antidepressants, food supplementAbstract
Depression affects more than 300 million people worldwide, and its treatment includes SSRIs, but they have a prolonged latency. Research suggests that curcuma could be a therapeutic alternative. In this study, the interactions between curcuma and fluoxetine were evaluated. The results showed that curcuma, both individually and in combination with subthreshold doses of fluoxetine, had antidepressant effects without altering renal and hepatic function. However, in effective combinations, it cancels out the effect, which is related to a pharmacological interaction. These findings suggest that curcuma could be a natural option for treating depression.
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Copyright (c) 2025 Jennifer Trujillo De Los Santos, Jonathan Cueto-Escobedo, Juan Francisco Rodríguez-Landa, Gabriel-Guillén Ruiz, Ana Karen Limón-Vázquez, Eduardo Rivadeneyra-Domínguez, Olga Lidia Valenzuela-Limón
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