PP2 Advances in the Pharmacokinetics of Herbal Natural Products and Implications for Their Therapeutic Use
DOI:
https://doi.org/10.3407/pg9mrm62Keywords:
Farmacocinética, productos naturales, extractos vegetales, interacciones herbalesAbstract
Plant preparations remain a widely consumed therapeutic option worldwide [1]. Despite being considered safe, the compounds present in them have the same potential to produce adverse reactions or clinically significant interactions as synthetic drugs. For this reason, the World Health Organization has encouraged countries to strengthen the regulation and research about natural medicine, which includes the study of its pharmacokinetics [2, 3].
References
[1] SALMERÓN, E., et al. (2020). Worldwide research trends on medicinal plants. Int J Environ Res Public Health, 17: 3376.
[2] World Health Organization (WHO). WHO Traditional Medicine Strategy 2014–2023. Geneva: World Health Organization, (2013). p. 1–76.
[3] U.S. Department of Health and Human Services, et al. Botanical Drug Development Guidance for Industry. Silver Spring: FDA, (2016). p. 1–30.
[4] DOMINGUEZ, G.P., et al. (2017). Pharmacokinetics of botanical drugs and plant extracts. Mini Rev Med Chem., 17: 646-1664.
[5] ZENG, W., et al. (2022). Effect of green tea extract and soy isoflavones on the pharmacokinetics of rosuvastatin in healthy volunteers. Front nutr., 9: 850318.
[6] PALOMARES, F., et al. (2020). Moringa oleifera extracts and praziquantel combination: Bioavailability in rats and cysticidal activity in a Murine model. Rev Bras Farmacogn., 30: 251–256.
[7] ABDELGAWAD, M.A., et al. (2022). Development and greenness assessment of HPLC method for studying the pharmacokinetics of co-administered metformin and papaya extract. Molecules, 27: 375.
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