PP97 Design and develop a self-emulsifying system prototype for topical application of Caribbean Colombian algae extracts with potential antimicrobial activity against acne-related microorganisms.
DOI:
https://doi.org/10.3407/2cv62r19Keywords:
Sistema autoemulsificable, Dictyota spp, acné, antimicrobianoAbstract
The exploration of topical acne treatments used Dictyota extracts collected in Providencia, Colombian Caribbean. These extracts showed antimicrobial activity against Staphylococcus epidermidis and Cutibacterium acnes, linked to diterpenes and fatty acids that disrupt bacterial membranes. Using matrices and pseudoternary diagrams, a self-emulsifying system was designed, optimizing critical variables such as droplet size (<100 nm) and negative zeta potential. Ex vivo, the prototype retained effectiveness and was distributed without anatomically altering the skin, according to Franz cell tests using porcine skin, reflecting its regulatory potential for compromised skin barriers.
References
[1] WANG, H. D., et al. (2017). Potential Biomedical Applications of Marine Algae. Bioresour Technol 244 (Pt 2): 1407-1415. [DOI]
[2] MAHIZAN, N. A., et al. (2019). Terpene Derivatives as a Potential Agent against Antimicrobial Resistance (Amr) Pathogens. Molecules 24(14). [DOI]
[3] VAN STADEN, D., et al. (2020). Development of a Self-Emulsifying Drug Delivery System for Optimized Topical Delivery of Clofazimine. Pharmaceutics 12(6). [DOI]
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Copyright (c) 2025 Ingrid Andrea Rodriguez Martinez, Marcela Aragón, Leonardo Castellanos
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