PO53 Chrysin and Genistein, from natural products to behavioral pharmacology
DOI:
https://doi.org/10.3407/x603qw05Keywords:
Crisina, Genisteína, Ansiolíticas, Antidepresivos, Farmacología conductualAbstract
Vascular plants naturally produce biologically active secondary metabolites that influence mammalian cellular function. Among these, polyphenols—particularly flavonoids—are widely distributed throughout the plant kingdom and are responsible for many of the colors, flavors, and medicinal properties found in fruits, flowers, herbs, and beverages such as tea and wine [1]. This study focuses on two flavonoids, chrysin and genistein, which have demonstrated pharmacological effects relevant to the treatment of anxiety and depression [2;3].
References
[1] GERMAN-PONCIANO, L. J., et al. (2018). Advances in the Preclinical Study of Some Flavonoids as Potential Antidepressant Agents. Scientifica 2018(1): 2963565. [DOI]
[2] THANGAVEL, P., et al. (2019). Genistein as Potential Therapeutic Candidate for Menopausal Symptoms and Other Related Diseases. Molecules 24(21): 3551. [DOI]
[3] RODRÍGUEZ-LANDA, J. F., et al. (2022). Pharmacological, Neurochemical, and Behavioral Mechanisms Underlying the Anxiolytic- and Antidepressant-Like Effects of Flavonoid Chrysin. Molecules 27(11): 3551. [DOI]
[4] RODRÍGUEZ-LANDA, J. F., et al. Chapter 5 - Phytoestrogens as Potential Therapeutic Agents for the Treatment of Anxiety and Affective Disorders. In: ATTA UR, R. (ed.). Studies in Natural Products Chemistry. Elsevier, (2018). p. 133-159. [DOI]
[5] GUILLÉN-RUIZ, G., et al. (2024). Involvement of the Gabaa Receptor in the Antidepressant-Like Effects Produced by Low and High Doses of the Flavonoid Chrysin in the Rat: A Longitudinal Study. JIN 23(3): 51-65. [DOI]
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Copyright (c) 2025 Blandina BERNAL-MORALES, Dr. Gabriel Guillén-Ruiz, Dr. Juan Francisco Rodríguez Landa
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