PP4 Potential Induction of Structural Neuroplasticity by an Active Fraction of Tillandsia usneoides and Its Chromatographic Profile by UHPLC-DAD-QTOF-MS
DOI:
https://doi.org/10.3407/e1ad7v76Keywords:
Tillandsia usneoides, flavonoids, neuroplasticity, signaling pathways.Abstract
Chemotherapeutic drugs have been observed to cause neurotoxicity, affecting neuroplasticity and leading to cognitive impairment. This study evaluated the potential of Tillandsia usneoides, a plant with neuroplasticity-inducing activity. Its ethyl acetate (AcOEt) fraction was chemically characterized and its ability to induce neuritogenesis and activate Erk and PI3K pathways in rat neurons was investigated. The results showed that the AcOEt fraction, rich in methoxylated flavonoids, promoted dendritic complexity, increasing branching and dendrite length, suggesting an important neuroplastic potential.
References
Tannock F, Ahles, TA. Ganz PA, and. van Dam F. Cognitive Impairment Associated With Chemotherapy for Cancer: Report of a Workshop. Journal of Clinical Oncology 2004; 22(1)
Cichon N, Saluk-Bijak J, Gorniak L, Przyslo L, Bijak M. Flavonoids as a Natural Enhancer of Neuroplasticity-An Overview of the Mechanism of Neurorestorative Action. Antioxidants (Basel). 2020;9(11):1035. doi: 10.3390/antiox9111035
Citri A y Malenka R. Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms. Neuropsychopharmacol.2008; 33, 18-41. https://doi.org/10.1038/sj.npp.1301559
Rodríguez A. Evaluación del efecto neuroprotector y de los cambios en la complejidad dendrítica inducidos por los extractos de Tillandsia usneoides y Lippia alba en cultivo primario de neuronas tratadas con agentes quimioterapéuticos. Tesis de Maestría. Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, 2021, 117pp
Downloads
Published
Issue
Section
Categories
License
Copyright (c) 2025 Maria Fernanda Sanchez Roncancio, Leonardo Villarreal Romero, Jhon Sutachan, Sonia Luz Albarracin Cordero, Geisson Modesti Costa
This work is licensed under a Creative Commons Attribution 4.0 International License.
License Terms
The Creative Commons Attribution License (CC BY 4.0) allows users to copy, distribute and transmit an article and adapt the article and make commercial use of the article. The CC BY license permits commercial and non-commercial re-use of an open access article, as long as the author is properly attributed.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
- You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation.
- No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity.
How to Cite
