PO19 Acute and chronic effect of Montanoa tomentosa infusion on despair-like and activation of hypothalamic oxytocinergic neurons in Wistar rats
DOI:
https://doi.org/10.3407/fn7s4216Keywords:
Montanoa tomentosa, anti-desesperanza, neuronas oxitocinérgicas, Núcleo Paraventricular, Núcleo SupraopticoAbstract
In preclinical studies, Montanoa tomentosa (Mt) has behavioral effects similar to those of the hormone oxytocin (OXT). However, the effect of its acute and chronic administration on brain structures and anti-hopelessness behavioral responses, compared with an antidepressant drug, is unknown. The results show that acute treatment with Mt, but not Fluoxetine, produces an anti-hopelessness effect, which could be associated with the activation of OXT cells. Chronic treatment with Mt exerts anti-hopelessness effects similar to those of Fluoxetine, independently of oxytocinergic activation in the paraventricular and supraoptic nuclei.
References
[1] LEVINE, S. D., et al. (1981). The Mexican Plant Zoapatle (Montanoa Tomentosa) in Reproductive Medicine. Past, Present and Future. J Reprod Med 26(10): 524-528. URL
[2] GALLEGOS, A. J. (1983). The Zoapatle I--a Traditional Remedy from Mexico Emerges to Modern Times. Contraception 27(3): 211-225. [DOI]
[3] PORSOLT, R. D., et al. (1978). Behavioural Despair in Rats: A New Model Sensitive to Antidepressant Treatments. Eur J Pharmacol 47(4): 379-391. [DOI]
[4] CONTRERAS, C. M., et al. (2001). The Lowest Effective Dose of Fluoxetine in the Forced Swim Test Significantly Affects the Firing Rate of Lateral Septal Nucleus Neurones in the Rat. J Psychopharmacol 15(4): 231-236. [DOI]
[5] CASTAGNE, V., et al. (2009). Use of Latency to Immobility Improves Detection of Antidepressant-Like Activity in the Behavioral Despair Test in the Mouse. Eur J Pharmacol 616(1-3): 128-133. [DOI]
[6] ARLETTI, R. y BERTOLINI, A. (1987). Oxytocin Acts as an Antidepressant in Two Animal Models of Depression. Life Sciences 41(14): 1725-1730. [DOI]
[7] LAGUNES-MERINO, O., et al. (2020). Acute Effect of an Infusion of Montanoa Tomentosa on Despair-Like Behavior and Activation of Oxytocin Hypothalamic Cells in Wistar Rats. J Tradit Complement Med 10(1): 45-51. [DOI]
[8] LAGUNES-MERINO, O., et al. (2020). Acute Effect of an Infusion of Montanoa Tomentosa on Despair-Like Behavior and Activation of Oxytocin Hypothalamic Cells in Wistar Rats. Journal of Traditional and Complementary Medicine 10(1): 45-51. [DOI]
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Copyright (c) 2025 Ma de Jesús Rovirosa Hernández, Dr. Juan Francisco Rodríguez-Landa, Jonathan Cueto-Escobedo, Daniel Hernández-Baltazar, Blandina Bernal-Morales, Francisco García-Orduña, Omar Lagunes-Merino
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