PP26 Anxiolytic effect of microinjection of the flavonoid chrysin into the dorsal hippocampus and administration of allopregnanolone in ovariectomized Wistar rats
DOI:
https://doi.org/10.3407/x37rwt53Keywords:
Anxiolytic, chrysin, dorsal hippocampus, ovariectomy, allopregnanolone, surgical menopause.Abstract
Systemic chrysin produces anxiolytic effects, but its effect on dorsal hippocampus and interaction with allopregnanolone are unknown. Eight groups were formed with ovariectomized rats and hippocampal implants. Control group, three groups with microinjection 0.25, 0.50, or 1.0 μg/rat. Four groups received allopregnanolone plus vehicle, 0.25, 0.50, or 1.0 μg/rat/chrysin. The groups were evaluated in elevated plus maze and open field. 0.50 μg/rat increased time spent in open arms similarly to allopregnanolone; this effect was canceled by allopregnanolone, possibly due to changes in GABA receptor affinity. We conclude that hippocampus regulates the anxiolytic effect of chrysin and interacts with allopregnanolone.
References
[1] STUTE, P. y LOZZA-FIACCO, S. (2022). Strategies to Cope with Stress and Anxiety During the Menopausal Transition. Maturitas 166: 1-13. [DOI]
[2] ENGIN, E. y TREIT, D. (2007). The Role of Hippocampus in Anxiety: Intracerebral Infusion Studies. Behavioural Pharmacology 18(5-6). URL
[3] RODRÍGUEZ-LANDA, J. F., et al. (2019). Chrysin (5,7-Dihydroxyflavone) Exerts Anxiolytic-Like Effects through Gabaa Receptors in a Surgical Menopause Model in Rats. Biomedicine & Pharmacotherapy 109: 2387-2395. [DOI]
[4] RODRÍGUEZ-LANDA, J. F., et al. (2022). Gabaa/Benzodiazepine Receptor Complex in the Dorsal Hippocampus Mediates the Effects of Chrysin on Anxiety-Like Behaviour in Female Rats. Frontiers in Behavioral Neuroscience Volume 15 - 2021. URL
Downloads
Published
Issue
Section
Categories
License
Copyright (c) 2025 Gabriel Guillen-Ruiz, Fabiola Hernández-López, Juan Francisco Rodríguez-Landa, Jonathan Cueto-Escobedo
This work is licensed under a Creative Commons Attribution 4.0 International License.
License Terms
The Creative Commons Attribution License (CC BY 4.0) allows users to copy, distribute and transmit an article and adapt the article and make commercial use of the article. The CC BY license permits commercial and non-commercial re-use of an open access article, as long as the author is properly attributed.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
- You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation.
- No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity.
How to Cite
