PO26 Amaryllidaceae Species: Source of Cytotoxic Alkaloids in Cancer of Epidemiological Relevance

Authors

  • Lina Marcela Trujillo Chacon Universidad de Antioquia https://orcid.org/0000-0003-2781-2490
  • Edison OSORIO DURANGO Universidad de Antioquia https://orcid.org/0000-0002-9821-3420
  • Yesin Hawer Leiva Cuenca Unidad de Biotecnología Vegetal, Facultad de Ingeniería, Universidad Católica de Oriente, Rionegro 054040, Colombia
  • Dagoberto CASTRO 2Unidad de Biotecnología Vegetal, Facultad de Ingeniería, Universidad Católica de Oriente, Rionegro 054040, Colombia

DOI:

https://doi.org/10.3407/trsdvx73

Keywords:

Cancer, cytotoxic activity, alkaloids, Amaryllidaceae species

Abstract

Cancer is a leading cause of death and a serious impediment to increasing life expectancy worldwide, with breast, prostate, stomach, lung, and uterine cancers being the most common in terms of incidence and mortality. Therefore, the objective of this research was to identify novel molecules for potential chemotherapeutic treatment of epidemiologically relevant cancers. We determined the cytotoxic activity of chemically characterized alkaloid fractions from ten introduced, native, and endemic Amaryllidaceae species in Colombia against gastric, lung, breast, prostate, and uterine cancer cell lines.

References

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[2] ARNOLD, M., et al. (2022). Current and Future Burden of Breast Cancer: Global Statistics for 2020 and 2040. Breast 66: 15-23. [DOI]

[3] LU, J. J. y WANG, Y. T. (2020). Identification of Anti-Cancer Compounds from Natural Products. Chin J Nat Med 18(7): 481-482. [DOI]

[4] NEWMAN, D. J. y CRAGG, G. M. (2020). Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. J Nat Prod 83(3): 770-803. [DOI]

[5] HOWES, M. R. (2018). The Evolution of Anticancer Drug Discovery from Plants. Lancet Oncol 19(3): 293-294. [DOI]

[6] NAIR, J. J., et al. Chapter 3 - Cytotoxic Alkaloid Constituents of the Amaryllidaceae. In: ATTA UR, R. (ed.). Studies in Natural Products Chemistry. Elsevier, (2016). p. 107-156. [DOI]

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Published

2025-06-03

How to Cite

PO26 Amaryllidaceae Species: Source of Cytotoxic Alkaloids in Cancer of Epidemiological Relevance. (2025). Revista Productos Naturales, 6(1), 105-107. https://doi.org/10.3407/trsdvx73