PO31 Study of inhibitory potential of some species of the genus Piper against Pancreatic Lipase
DOI:
https://doi.org/10.3407/zsscf904Keywords:
Piper, enzymatic inhibition, pancreatic lipase, obesity, chromenes, chromansAbstract
Pancreatic lipase (PL) is a key enzyme in lipid digestion and a widely studied therapeutic target for obesity treatment. Inhibition of PL reduces fat absorption and promotes weight loss; however, available drugs have limitations related to adverse effects and variable efficacy [1]. This situation has driven the search for safer natural alternatives, among which plants of the Piper genus (Piperaceae) known for their diversity of secondary metabolites, some of which can inhibit digestive enzymes such as PL [2].
References
[1] PRIETO-RODRIGUEZ, J. A., et al. (2022). In Vitro and in Silico Study of the Alpha-Glucosidase and Lipase Inhibitory Activities of Chemical Constituents from Piper Cumanense (Piperaceae) and Synthetic Analogs. Plants (Basel) 11(17). [DOI]
[2] LIU, T.-T., et al. (2020). Lipase Inhibitors for Obesity: A Review. Biomedicine & Pharmacotherapy 128: 110314. [DOI]
[3] VO, C.-V. T., et al. (2022). Screening for Pancreatic Lipase Inhibitors: Evaluating Assay Conditions Using P-Nitrophenyl Palmitate as Substrate. All Life 15(1): 13-22. [DOI]
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Copyright (c) 2025 Wendy Lorena Gomez Alvarado, Oscar Javier Ladino Patiño, Juliet Angélica Prieto Rodriguez
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