PP13 Bioactive Alkaloids from Two Amaryllidaceae Species: Cytotoxic Potential Against Gastric Cancer Cells

Autores

  • Sergio Gonzalez Lopez Grupo de Investigación en Sustancias Bioactivas GISB, Facultad de Ciencias Farmacéuticas y Alimentarias, Universidad de Antioquia, Calle 70 No. 52-21, Medellín 0500100, Colombia
  • Lina Marcela Trujillo Chacón Grupo de Investigación en Sustancias Bioactivas GISB, Facultad de Ciencias Farmacéuticas y Alimentarias, Universidad de Antioquia, Calle 70 No. 52-21, Medellín 0500100, Colombia
  • Edison Javier Osorio Durango Grupo de Investigación en Sustancias Bioactivas GISB, Facultad de Ciencias Farmacéuticas y Alimentarias, Universidad de Antioquia, Calle 70 No. 52-21, Medellín 0500100, Colombia https://orcid.org/0000-0002-9821-3420

DOI:

https://doi.org/10.3407/85bd4r28

Palavras-chave:

Amaryllidaceae, Caliphruria subedentata, Phaedranassa lehmannii, Cytotoxic activity, Gastric cancer

Resumo

Cancer is a significant health problem and one of the main causes of death in the world [1]. Chemotherapy is one of the most common treatments [2], and Amaryllidaceae alkaloids represent promising cytotoxic agents and potential chemotherapeutics against various types of cancer [3;4]

Referências

Cancer [Internet]. [cited 2025 Mar 28]. Available from: https://www.who.int/news-room/fact-sheets/detail/cancer

Treatment For Cancer | Cancer Treatment Options [Internet]. [cited 2025 Mar 28]. Available from: https://www.cancer.org/cancer/managing-cancer/treatment-types.html

Nair JJ, Van Staden J. The plant family Amaryllidaceae as a source of cytotoxic homolycorine alkaloid principles. South African Journal of Botany. 2021 Jan 1; 136:157–74.

Tallini LR, Machado das Neves G, Vendruscolo MH, Rezende-Teixeira P, Borges W, Bastida J, et al. Antitumoral activity of different Amaryllidaceae alkaloids: In vitro and in silico assays. Journal of Ethnopharmacology. 2024 Jul 15; 329:118154.

Lekhak MM, Patel SB, Otari SS, Lekhak UM, Ghane SG. Bioactive potential and RP-HPLC detection of phenolics and alkaloids (lycorine and galanthamine) from ultrasonic-assisted extracts of Crinum roots. South African Journal of Botany. 2022 Sep 1; 149:923–36.

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Publicado

2025-07-19

Como Citar

Gonzalez Lopez, S., Trujillo Chacón, L. M., & Osorio Durango, E. J. (2025). PP13 Bioactive Alkaloids from Two Amaryllidaceae Species: Cytotoxic Potential Against Gastric Cancer Cells. Revista Productos Naturales, 6(1), 252-254. https://doi.org/10.3407/85bd4r28