CP-6 Modification of natural products by the Chan-Lam reaction: Chemical space expansion and antibacterial activity
DOI:
https://doi.org/10.3407/rpn.v6i1cp1Keywords:
Boldine, viridicatin , isovanillin, Chan-Lam coupling, Copper-catalyzedAbstract
Natural products play a crucial role in drug discovery and development, as evidenced by the fact that approximately 75% of antibacterial compounds introduced clinically in the last 40 years are derived from natural sources, including microbes, plants, and animalsReferences
1. Koehn, F., Carter, G. The evolving role of natural products in drug discovery. Nat Rev Drug Discov 4, 206–220 (2005). [DOI].
2. P. J. Wickhorst, M. Blachnik, D. Lagumdzija and H. Ihmels, Beilstein J. Org. Chem., 2021, 17, 991-1000. [DOI]
3. O. A. Sánchez-Velasco, J. Saavedra-Olavarría, D. A. A. Araya-Santelices, P. Hermosilla-Ibáñez, B. K. Cassels and E. G. Pérez, J. Nat. Prod., 2021, 84, 1985-1992. [DOI]
4. M. Liu and P. J. Dyson, Nat. Commun., 2023, 14, 2830-2837. [DOI]
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