PO5 Gene and Metabolite Analysis Linked to Pentacyclic Acidic Triterpene Biosynthesis in C. angustifolia Roots
DOI:
https://doi.org/10.3407/ce5bea39Keywords:
triterpenos pentacíclicos ácidos, Enzimas, metabolismo secundario, CecropiaAbstract
Cecropia angustifolia, a native plant of the American continent, biosynthesizes a group of secondary metabolites known as pentacyclic acidic triterpenes (TPAs) in its roots. These molecules have potential pharmaceutical applications due to their reported modulatory effects on metabolic diseases such as Type 2 Diabetes Mellitus, as they help reduce biochemical markers associated with this condition.
References
[1] FANANI, M. Z., et al. (2019). Molecular Basis of C-30 Product Regioselectivity of Legume Oxidases Involved in High-Value Triterpenoid Biosynthesis. Frontiers in Plant Science Volume 10 - 2019. URL
[2] GUTIÉRREZ, G., et al. Pentacyclic Triterpene Profile and Its Biosynthetic Pathway in Cecropia Telenitida as a Prospective Dietary Supplement. Molecules. (2021). [DOI]
[3] CADENA-ZAMUDIO, J. D., et al. Integrated Analysis of the Transcriptome and Metabolome of Cecropia Obtusifolia: A Plant with High Chlorogenic Acid Content Traditionally Used to Treat Diabetes Mellitus. International Journal of Molecular Sciences. (2020). [DOI]
[4] HU, D., et al. 1.18 - Biosynthesis of Triterpenoid Natural Products. In: LIU, H.-W.yBEGLEY, T. P. (eds.). Comprehensive Natural Products Iii. Oxford: Elsevier, (2020). p. 577-612. [DOI]
[5] SØREN, B., et al. (2011). Cytochromes P450. The Arabidopsis Book 2011(9). [DOI]
[6] GHOSH, S. (2017). Triterpene Structural Diversification by Plant Cytochrome P450 Enzymes. Front Plant Sci 8: 1886. [DOI]
[7] MIETTINEN, K., et al. (2017). The Ancient Cyp716 Family Is a Major Contributor to the Diversification of Eudicot Triterpenoid Biosynthesis. Nature Communications 8(1): 14153. [DOI]
[8] VASQUEZ-DELGADO, J. S., et al. (2023). Pharmacokinetic Assessment and Phytochemical Triterpene Control from Cecropia Angustifolia Using Plant Biotechnology. Phytochem Anal 34(6): 641-651. [DOI]
Downloads
Published
Issue
Section
Categories
License
Copyright (c) 2025 Paula Catherine MUÑOZ BONILLA
This work is licensed under a Creative Commons Attribution 4.0 International License.
License Terms
The Creative Commons Attribution License (CC BY 4.0) allows users to copy, distribute and transmit an article and adapt the article and make commercial use of the article. The CC BY license permits commercial and non-commercial re-use of an open access article, as long as the author is properly attributed.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
- You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation.
- No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity.
How to Cite
