PO12 Chemical characterization, antiplasmodial activity against P. falciparum (W2) and cytotoxicity of the ethanolic extract and fractions of Curarea toxicofera (Wedd.) Barneby & Krukoff
DOI:
https://doi.org/10.3407/bwvksm42Keywords:
Bisbenzylisoquinoline alkaloids, menispermaceae, antiplasmodial activity, cytotoxicityAbstract
Malaria is a parasitic disease present in the tropics. According to the world malaria report of 2023, an estimated of 249 million cases and 11.7 million deaths were reported worldwide in 2022 [1]. Curarea toxicofera (Menispermaceae) is a native neotropical plant, traditionally used in the treatment of malaria by the Hitoma community in Amazonas-Colombia. In a previous study, this plant showed a promising in vitro antiplasmodial activity (IC50 = 8 ± 3.9 μg/mL) [2]. Therefore, it was chosen to continue its chemical and biological characterization.
References
1. OMS. (2023). World malaria report 2023. URL
2. Hernández-Carvajal, J. E., Arias-Marciales, M. H., García, J. O., Hata-Uribe, Y. A., Garavito-Cárdenas, G., & Caicedo, P. E. L. (2022). Phytochemical and antiplasmodial evaluation of five Colombian plants with ethnopharmacological background of antimalarial use. Pharmaceutical Sciences. [DOI]
3. Willcox, M., Bodeker, G., Rasoanaivo, P., & Addae-Kyereme, J. (Eds.). (2004). Traditional Medicinal Plants and Malaria (1st ed.). CRC Press. [DOI]
4. Osorio, E., Arango, G. J., Jiménez, N., Alzate, F., Ruiz, G., Gutiérrez, D., Paco, M. A., Giménez, A., & Robledo, S. (2007). Antiprotozoal and cytotoxic activities in vitro of Colombian Annonaceae. Journal of Ethnopharmacology, 111(3), 630-635. [DOI]
5. Tshibangu, J. N., Wright, A. D., & König, G. M. (2003). HPLC isolation of the anti-plasmodially active bisbenzylisoquinone alkaloids present in roots of Cissampelos mucronata. Phytochemical Analysis: PCA, 14(1), 13-22. [DOI]
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Copyright (c) 2025 Jorge Enrique Hernández Carvajal, Maria Fernanda Alves, Alaíde Braga de Oliveira, Geraldo Célio Brandão, Yoshie Adriana Hata , Giovanny Garavito C, Pilar Ester Luengas C
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