PO55 Preclinical Evaluation of a Self-Emulsifying Delivery System Loaded with a Passiflora ligularis extract: A Potential Alternative in the Treatment of Diabetes Mellitus
DOI:
https://doi.org/10.3407/j1kv6p78Keywords:
sistema autoemulsificable, Passiflora ligularis, diabetes, estreptozocinaAbstract
Colombia is one of the countries with the greatest biodiversity of Passifloras in the world. This genus has been extensively studied due to its antioxidant and anti-inflammatory properties, particularly for the species Passiflora ligularis, which has been reported to have antihyperglycemic effects in acute in vivo models [1;2]. This activity was associated with the presence of O-glycosylated flavonoids derived from quercetin, kaempferol, and chrysin [3;4].
References
[1] ECHEVERRY, S. M., et al. (2021). Development of a Self-Emulsifying Drug Delivery System (Sedds) to Improve the Hypoglycemic Activity of Passiflora Ligularis Leaves Extract. Journal of Drug Delivery Science and Technology 64: 102604. [DOI]
[2] SEPÚLVEDA, P. M., et al. (2020). Passiflora Ligularis Leaf Ultrasound-Assisted Extraction in the Optimization of Flavonoid Content and Enhancement of Hypoglycemic Activity. Journal of Applied Pharmaceutical Science 10(8): 86-94. [DOI]
[3] SARAVANAN, S. y PARIMELAZHAGAN, T. (2014). In Vitro Antioxidant, Antimicrobial and Anti-Diabetic Properties of Polyphenols of Passiflora Ligularis Juss. Fruit Pulp. Food Science and Human Wellness 3(2): 56-64. [DOI]
[4] MONZÓN DAZA, G., et al. (2021). Identification of Α-Amylase and Α-Glucosidase Inhibitors and Ligularoside a, a New Triterpenoid Saponin from Passiflora Ligularis Juss (Sweet Granadilla) Leaves, by a Nuclear Magnetic Resonance-Based Metabolomic Study. Journal of Agricultural and Food Chemistry 69(9): 2919-2931. [DOI]
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Copyright (c) 2025 Sandra Milena ECHEVERRY GONZÁLEZ, Dr. Diana Marcela Aragón, Bibiana Verlindo de Araujo, Fatima Regina Mena Barreto Silva, Diana P. Rey, Ivonne H. Valderrama, Ingrid A. Rodriguez
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