PO23 Harnessing Drosophila melanogaster for Bioactive Natural Product Discovery

Authors

  • Erika Plazas Profesor https://orcid.org/0000-0002-4072-667X
  • Ivonne Gonzalez Grupo de investigación FARMABIOTEC, Facultad de Ciencias Exactas y Naturales, Fundación Universitaria Salesiana, Bogotá, Colombia
  • Cecilia Rincón Prieto Grupo de investigación FARMABIOTEC, Facultad de Ciencias Exactas y Naturales, Fundación Universitaria Salesiana, Bogotá, Colombia https://orcid.org/0009-0003-7943-4900
  • Diego Ricardo Muñoz Grupo de investigación FARMABIOTEC, Facultad de Ciencias Exactas y Naturales, Fundación Universitaria Salesiana, Bogotá, Colombia

DOI:

https://doi.org/10.3407/85vn2v70

Keywords:

In vivo models, Fruit fly, Neuroprotective, Diabetes, Extracts, Medicinal plants

Abstract

Drosophila melanogaster is a powerful model for bioactive compound discovery due to its genetic tractability, short life cycle, and physiological similarities to humans. About 75% of human disease-related genes have orthologs in Drosophila, making it ideal for high-throughput screenings. Here, we explore its use in evaluating medicinal plant extracts for neuroprotection and diabetes. Tagetes zypaquierensis (1000 ppm) improved locomotion in neurotoxin-exposed flies, while Juglans neotropica reduced lipid and carbohydrate levels in diabetic flies. These findings highlight Drosophila as a cost-effective, high-throughput platform for assessing toxicity and pharmacological potential in early-stage natural product research.

References

[1] LOPEZ-ORTIZ, C., et al. Drosophila Melanogaster as a Translational Model System to Explore the Impact of Phytochemicals on Human Health. International Journal of Molecular Sciences. (2023). [DOI]

[2] WEI, G., et al. Dme-Hsa Disease Database (Dhdd): Conserved Human Disease-Related Mirna and Their Targeting Genes in Drosophila Melanogaster. International Journal of Molecular Sciences. (2018). [DOI]

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Published

2025-06-30

How to Cite

PO23 Harnessing Drosophila melanogaster for Bioactive Natural Product Discovery. (2025). Revista Productos Naturales, 6(1), 96-98. https://doi.org/10.3407/85vn2v70