PO17 Contribution to the chemical study of the bioactive compounds of Streptomyces 5.1 against the phytopathogen Colletotrichum gloeosporioides: A chemical approach in the search for natural antifungal agents

Authors

  • Edison Javier Jaimes Cáceres Estudiante https://orcid.org/0009-0006-7533-105X
  • Leonardo Castellanos Hernández Facultad de Ciencias, Universidad Nacional de Colombia, sede Bogotá
  • Freddy Alejandro Ramos Rodríguez Facultad de Ciencias, Universidad Nacional de Colombia, sede Bogotá

DOI:

https://doi.org/10.3407/7yy03k02

Keywords:

Biocontrol, antracnosis, RMN, LC-MS/MS, BHMF

Abstract

The present study aimed to analyze the extracts from the culture of Streptomyces 5.1 to identify the metabolites responsible for the antifungal activity observed against the phytopathogen Colletotrichum gloeosporioides, which affects avocado crops and causes significant economic losses [1; 2]. The methodology involved culturing the microorganism in two different media (M3.7 with salts and GYM [3] at a scale of 15 liters, followed by an evaluation of the antifungal activity of the obtained extracts. 

Author Biographies

  • Edison Javier Jaimes Cáceres, Estudiante

    Chemistry student with a background in natural products, experienced in the extraction of active compounds from microbial sources and the determination of antifungal activity using various methods, such as agar well diffusion assays. Trained in molecular networking tools for the study and analysis of microbial extracts and in NMR spectroscopy for metabolite elucidation.

  • Leonardo Castellanos Hernández, Facultad de Ciencias, Universidad Nacional de Colombia, sede Bogotá

    Professor Castellanos holds a Master's and Ph.D. in Chemistry from the National University of Colombia, along with postdoctoral experience in metabolomics from Leiden University, Netherlands. His expertise in organic chemistry encompasses marine natural products chemistry, the chemical study of microorganisms, biotechnology, metabolomics, and semisynthesis. With over 80 publications focusing on natural products, particularly marine organisms and Passiflora species, he is recognized as a Senior Researcher by Minciencias and currently serves as a full professor of Organic Chemistry at the National University of Colombia.

  • Freddy Alejandro Ramos Rodríguez, Facultad de Ciencias, Universidad Nacional de Colombia, sede Bogotá

    Chemist and MSc in Chemistry from the National University of Colombia. PhD in Pharmaceutical Sciences from the University of Tokushima (Japan). Full Professor at the National University of Colombia and Senior Researcher at Minciencias since 2014. Expert in Natural Products Chemistry, with extensive experience in the isolation, purification, and characterization of complex organic compounds from marine invertebrates, microorganisms, and plants. Proficient in the use of state-of-the-art instrumental techniques, such as multidimensional NMR and high-resolution LC-MS.

    In recent years, my research has focused on the discovery of secondary metabolites with biotechnological potential, with a particular emphasis on the development of marine biocontrol agents for sustainable agriculture through metabolomic approaches. Supervisor of three PhD dissertations, 17 master's theses, and over 30 undergraduate research projects. Author of more than 65 research articles. Coordinator of the Nuclear Magnetic Resonance Laboratory at the Bogotá campus.

References

[1] ROMERO VELANDIA, P. A. Formulación Y Evaluación De Un Bio-Recubrimiento a Base De Almidón De Yuca Modificado Con Aceite Esencial De Tomillo, Quitosano Y Ácido Tánico Para La Mitigación Del Hongo Colletotrichum gloeosporioides Aislado Del Aguacate Hass. (Ingeniería Química y de Alimentos). Universidad de los Andes. Facultad de Ingeniería. (2021).

[2] TAPIA RODRÍGUEZ, A., et al. (2020). Distribución Espacial De Antracnosis (Colletotrichum Gloeosporioides Penz) En Aguacate En El Estado De México, México. Revista Argentina de Microbiología 52(1): 72-81. [DOI]

[3] MOSQUERA FALLA, M. E. Estudio Químico De Streptomyces 5.1. (Farmacia). Universidad Nacional de Colombia. Facultad de Ciencias. (2018).

[4] DRICHE, E. H., et al. (2022). A New Saharan Strain of Streptomyces Sp. Gsb-11 Produces Maculosin and N-Acetyltyramine Active against Multidrug-Resistant Pathogenic Bacteria. Current Microbiology 79(10): 298. [DOI]

[5] MASI, M., et al. (2022). Truncatenolide, a Bioactive Disubstituted Nonenolide Produced by Colletotrichum Truncatum, the Causal Agent of Anthracnose of Soybean in Argentina: Fungal Antagonism and Sar Studies. Journal of Agricultural and Food Chemistry 70(32): 9834-9844. [DOI]

[6] PHUAKJAIPHAEO, C., et al. (2016). Isolation and Identification of an Antifungal Compound from Endophytic Streptomyces Sp. Cen26 Active against Alternaria Brassicicola. Letters in Applied Microbiology 63(1): 38-44. [DOI]

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Published

2025-06-03

How to Cite

PO17 Contribution to the chemical study of the bioactive compounds of Streptomyces 5.1 against the phytopathogen Colletotrichum gloeosporioides: A chemical approach in the search for natural antifungal agents. (2025). Revista Productos Naturales, 6(1), 78-80. https://doi.org/10.3407/7yy03k02