PO54 Eucharis formosa ALKALOIDS AS POTENTIAL CYTOTOXIC AGENTS IN BREAST CANCER

Authors

DOI:

https://doi.org/10.3407/rpn.v6i1po54

Keywords:

Eucharis formosa, Alkaloids, Cytotoxic activity, Breast cancer, GC-MS

Abstract

Natural products have been an important source for the discovery of new bioactive compounds with anticancer properties [1,3]. Therefore, plants of the Amaryllidaceae family represent a promising source of bioactive compounds as an alternative to conventional treatments [1–4]. This study aimed to analyze Eucharis formosa alkaloids through a bioguided study to determine the cytotoxic activity in the breast cancer cell line MDA-MB-231 [5,7]

References

[1] HAVELEK, R., MUTHNA, D., TOMSIK, P., KRALEVEC, K., SEIFRTOVA, M., CAHLIKOVA, L., et al. (2017). Anticancer potential of Amaryllidaceae alkaloids evaluated by screening with a panel of human cells, real‑time cellular analysis and Ehrlich tumor‑bearing mice. Chemico-Biological Interactions, 275: 121–132.[DOI]

[2] DUMONT, P., INGRASSIA, L., ROUZEAU, S., RIBAUCOUR, F., THOMAS, S., ROLAND, I., et al. (2007). The Amaryllidaceae isocarbostyril narciclasine induces apoptosis by activation of the death receptor and/or mitochondrial pathways in cancer cells but not in normal fibroblasts. Neoplasia, 9(9): 766–776.[DOI]

[3] NAIR, J. J., & VAN STADEN, J. (2021). The plant family Amaryllidaceae as a source of cytotoxic homolycorine alkaloid principles. South African Journal of Botany, 136: 157–174. [DOI]

[4] TRUJILLO, L., BEDOYA, J., CORTÉS, N., OSORIO, E. H., GALLEGO, J. C., LEIVA, H., et al. (2023). Cytotoxic activity of Amaryllidaceae plants against cancer cells: Biotechnological, in vitro, and in silico approaches. Molecules, 28(6). [URL]

[5] SUN, Y., GU, Y., GAO, X., JIN, X., WINK, M., SHAROPOV, F. S., et al. (2023). Lycorine suppresses the malignancy of breast carcinoma by modulating epithelial–mesenchymal transition and β‑catenin signaling. Pharmacological Research, 195: 106866. [DOI]

[6] MALICH, G., MARKOVIC, B., & WINDER, C. (2007). The MTT/MTS in vitro cell proliferation assay as a tool for evaluating cytotoxicity of extracted materials and natural products. PubMed.[URL]

[7] AMERICAN TYPE CULTURE COLLECTION (ATCC). (2023). MDA‑MB‑231 (HTB‑26) Cell Line. ATCC. [URL]

Downloads

Published

2026-01-20

How to Cite

Muñoz Potosí, E. (2026). PO54 Eucharis formosa ALKALOIDS AS POTENTIAL CYTOTOXIC AGENTS IN BREAST CANCER. Revista Productos Naturales, 6(1), 189-191. https://doi.org/10.3407/rpn.v6i1po54