PO21 Effect of the flavonoid chrysin on behavioral hopelessness in a Wistar rat model of surgical menopause
DOI:
https://doi.org/10.3407/bx5st738Keywords:
Menopausia quirúrgica, Crisina, Depresión, clorimipramina, flavonoideAbstract
Forty-two rats 12 weeks post-ovariectomy were enrolled in six groups. One group received vehicle; four groups received chrysin (doses: 0.5, 1, 2, and 4 mg/kg), and another received 2.5 mg/kg of chlorimipramine. Treatments were administered for 14 days; behavioral tests were performed one hour after the last administration. In the open field test, treatment with 4 mg/kg of chrysin and chlorimipramine decreased the number of square crossings and increased vertical behavior. In the swimming test, they significantly increased the latency to immobility and decreased the immobility time.
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[2] OLMOS-VÁZQUEZ OJ., et al. (2020). Antidepressant effects of fluoxetine in natural and surgical menopause: Preclinical and clinical research. In: Berhardt LV (ed.). Advance in medicine and biology. New York: Nova Science Publisher, Inc. 2020; Vol. 157, pp. 139-170.
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[4] FILHO CB., et al. (2016). Neurochemical factors associated with the antidepressant-like effect of flavonoid chrysin in chronically stressed mice. Eur J Pharmacol. 2016 Nov 15;791:284-296.
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