PP36 Estudio del Potencial Inhibitorio sobre Lipasa Pancréatica de Algunos Componentes Químicos Provenientes de Piper asperiusculum (Piperaceae)

Authors

DOI:

https://doi.org/10.3407/rpn.v6i1pp36

Keywords:

Obesidad, lipasa pancreática, piper asperiusculum, piper, cromenos

Abstract

Pancreatic lipase (PL) is a key enzyme in lipid digestion and a widely studied therapeutic target for obesity treatment. Inhibition of PL reduces fat absorption and promotes weight loss; however, available drugs have limitations related to adverse effects and variable efficacy [1]. This situation has driven the search for safer natural alternatives, among which plants of the Piper genus (Piperaceae) known for their diversity of secondary metabolites, some of which can inhibit digestive enzymes such as PL [2].

References

[1] PRIETO-RODRIGUEZ, J. A., et al. (2022). In Vitro and in Silico Study of the Alpha-Glucosidase and Lipase Inhibitory Activities of Chemical Constituents from Piper Cumanense (Piperaceae) and Synthetic Analogs. Plants (Basel) 11(17). [doi]

[2] LIU, T.-T., et al. (2020). Lipase Inhibitors for Obesity: A Review. Biomedicine & Pharmacotherapy 128: 110314. [doi]

[3] VO, C.-V. T., et al. (2022). Screening for Pancreatic Lipase Inhibitors: Evaluating Assay Conditions Using P-Nitrophenyl Palmitate as Substrate. All Life 15(1): 13-22. [doi]

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Published

2026-01-21

Issue

Vol. 6 No. 1 (2025): I Colombian Congress of Natural Products (2025)

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Abstract

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Copyright (c) 2026 Paula Alejandra Arguello Quevedo, Oscar Javier Patiño Ladino, Juliet Angélica Prieto Rodríguez, Diego Alejandro Silva Carrero

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How to Cite

Arguello Quevedo, P. A., Patiño Ladino, O. J., Prieto Rodríguez, J. A., & Silva Carrero, D. A. (2026). PP36 Estudio del Potencial Inhibitorio sobre Lipasa Pancréatica de Algunos Componentes Químicos Provenientes de Piper asperiusculum (Piperaceae). Revista Productos Naturales, 6(1), 321-323. https://doi.org/10.3407/rpn.v6i1pp36