PP30 Effect of the phytoestrogen genistein on anxiety-like behavior associated with the estrous cycle in Wistar rats
DOI:
https://doi.org/10.3407/5rnc0147Keywords:
genistein, anxiety, proestrus-estrus, metestrus-estrus, 17β-estradiol, phytoestrogensAbstract
In female rats, during the metaestrus-diestrus phases, a higher state of anxiety is detected, which is prevented with 17β-estradiol, but it is associated with the activation of oncogenes. Therefore, alternatives such as genistein are proposed. Three experimental groups were included: vehicle, genistein, and 17β-estradiol. The animals were evaluated in the elevated plus-maze (EPM) and locomotor activity tests. They were divided into subgroups according to the phase of the estrous cycle. The vehicle group during the M-D phase spent less time in the open arms and showed a higher anxiety index in the EPM, an effect that was prevented with genistein.
References
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Copyright (c) 2025 Ana Karen Limón-Vázquez, Oscar Jerónimo Olmos-Vázquez , Carlos Fabrizio Quiñonez-Bailón , Gabriel Guillén-Ruiz, Jonathan Cueto-Escobedo, Eduardo Rivadeneyra-Domínguez, Blandina Bernal-Morales, Juan Francisco Rodríguez-Landa
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